A novel gnd mutation leading to increased L-lysine production in Corynebacterium glutamicum

ArticleFems Microbiology Letters. 242(2): 265-274 (2005)journal articl

Hubbard band or oxygen vacancy states in the correlated electron metal SrVO3_3?

We study the effect of oxygen vacancies on the electronic structure of the model strongly correlated metal SrVO$_3$. By means of angle-resolved photoemission (ARPES) synchrotron experiments, we investigate the systematic effect of the UV dose on the measured spectra. We observe the onset of a spurious dose-dependent prominent peak at an energy range were the lower Hubbard band has been previously reported in this compound, raising questions on its previous interpretation. By a careful analysis of the dose dependent effects we succeed in disentangling the contributions coming from the oxygen vacancy states and from the lower Hubbard band. We obtain the intrinsic ARPES spectrum for the zero-vacancy limit, where a clear signal of a lower Hubbard band remains. We support our study by means of state-of-the-art ab initio calculations that include correlation effects and the presence of oxygen vacancies. Our results underscore the relevance of potential spurious states affecting ARPES experiments in correlated metals, which are associated to the ubiquitous oxygen vacancies as extensively reported in the context of a two-dimensional electron gas (2DEG) at the surface of insulating $d^0$ transition metal oxides.Comment: Manuscript + Supplemental Material, 12 pages, 9 figure

Beam Halo Imaging with a Digital Optical Mask

Beam halo is an important factor in any high intensity accelerator. It can cause difficulties in the control of the beam, emittance growth, particle loss and even damage to the accelerator. It is therefore essential to understand the mechanisms of halo formation and its dynamics in order to control and minimize its effects. Experimental measurement of the halo distribution is an important tool for such studies. In this paper, we present a new adaptive masking method that we have developed to image beam halo, which uses a digital micro-mirror-array device (DMD). This method has been thoroughly investigated in the laboratory using laser and white light sources, and with real beams produced by the University of Maryland Electron Ring (UMER). A high dynamic range ~10(5) has been demonstrated with this new method and recent studies indicate that this number can be exceeded for more intense beams by at least an order of magnitude. The method is flexible, easy to setup and can be used at any accelerator or light source. We present the results of our measurements of the performance of the method and images of beam halos produced under various experimental conditions.Comment: 44 pgs.; submitted to Phys. Rev. ST Accel. and Beams, 3/9/201

Evidence for phase formation in potassium intercalated 1,2;8,9-dibenzopentacene

We have prepared potassium intercalated 1,2;8,9-dibenzopentacene films under vacuum conditions. The evolution of the electronic excitation spectra upon potassium addition as measured using electron energy-loss spectroscopy clearly indicate the formation of particular doped phases with compositions K$_x$dibenzopentacene ($x$ = 1,2,3). Moreover, the stability of these phases as a function of temperature has been explored. Finally, the electronic excitation spectra also give insight into the electronic ground state of the potassium doped 1,2;8,9-dibenzopentacene films.Comment: 6 pages, 5 figures. arXiv admin note: text overlap with arXiv:1201.200

Absorption of Scintillation Light in a 100 ℓ\ell Liquid Xenonγ\gamma Ray Detector and Expected Detector Performance

An 800L liquid xenon scintillation $\gamma$ ray detector is being developed for the MEG experiment which will search for $\mu^+\to\mathrm{e}^+\gamma$ decay at the Paul Scherrer Institut. Absorption of scintillation light of xenon by impurities might possibly limit the performance of such a detector. We used a 100L prototype with an active volume of 372x372x496 mm$^3$ to study the scintillation light absorption. We have developed a method to evaluate the light absorption, separately from elastic scattering of light, by measuring cosmic rays and $\alpha$ sources. By using a suitable purification technique, an absorption length longer than 100 cm has been achieved. The effects of the light absorption on the energy resolution are estimated by Monte Carlo simulation.Comment: 18 pages, 10 figures (eps). Submitted to Nucl. Instr. and Meth.

High-density two-dimensional electron system induced by oxygen vacancies in ZnO

We realize a two-dimensional electron system (2DES) in ZnO by simply depositing pure aluminum on its surface in ultra-high vacuum, and characterize its electronic structure using angle-resolved photoemission spectroscopy. The aluminum oxidizes into alumina by creating oxygen vacancies that dope the bulk conduction band of ZnO and confine the electrons near its surface. The electron density of the 2DES is up to two orders of magnitude higher than those obtained in ZnO heterostructures. The 2DES shows two $s$-type subbands, that we compare to the $d$-like 2DESs in titanates, with clear signatures of many-body interactions that we analyze through a self-consistent extraction of the system self-energy and a modeling as a coupling of a 2D Fermi liquid with a Debye distribution of phonons.Comment: Article + Supplementary Material, 12 pages, 3 main figures, 6 supplementary figure

Mutations in the Satellite Cell Gene MEGF10 Cause a Recessive Congenital Myopathy with Minicores

We ascertained a nuclear family in which three of four siblings were affected with an unclassified autosomal recessive myopathy characterized by severe weakness, respiratory impairment, scoliosis, joint contractures, and an unusual combination of dystrophic and myopathic features on muscle biopsy. Whole genome sequence from one affected subject was filtered using linkage data and variant databases. A single gene, MEGF10, contained nonsynonymous mutations that co-segregated with the phenotype. Affected subjects were compound heterozygous for missense mutations c.976T > C (p.C326R) and c.2320T > C (p.C774R). Screening the MEGF10 open reading frame in 190 patients with genetically unexplained myopathies revealed a heterozygous mutation, c.211C > T (p.R71W), in one additional subject with a similar clinical and histological presentation as the discovery family. All three mutations were absent from at least 645 genotyped unaffected control subjects. MEGF10 contains 17 atypical epidermal growth factor-like domains, each of which contains eight cysteine residues that likely form disulfide bonds. Both the p.C326R and p.C774R mutations alter one of these residues, which are completely conserved in vertebrates. Previous work showed that murine Megf10 is required for preserving the undifferentiated, proliferative potential of satellite cells, myogenic precursors that regenerate skeletal muscle in response to injury or disease. Here, knockdown of megf10 in zebrafish by four different morpholinos resulted in abnormal phenotypes including unhatched eggs, curved tails, impaired motility, and disorganized muscle tissue, corroborating the pathogenicity of the human mutations. Our data establish the importance of MEGF10 in human skeletal muscle and suggest satellite cell dysfunction as a novel myopathic mechanism

Hydrogen Sulfide Protects HUVECs against Hydrogen Peroxide Induced Mitochondrial Dysfunction and Oxidative Stress

10.1371/journal.pone.0053147PLoS ONE82